; Voos, J.E. The system facilitates monitoring cancer progression and enables enhanced cancer management. Du, Y.; Tu, L.; Zhu, P.; Mu, M.; Wang, R.; Yang, P.; Wang, X.; Hu, C.; Ping, R.; Hu, P.; et al. ; Lyall, D.M. This technology could be used to detect diseases in underdeveloped areas to reduce the effects of disease and improve quality of life in these areas.

Microfluidic POC devices using DEP technology.

Microfluidics will play a vital role in the revolution in point of care diagnostics that is set to take place over the next decade. Dynamic propagation and impact of pandemic influenza A (2009 H1N1) in children: A detailed review.

microfluidic; POC (point-of-care); medical testing; COVID-19; wearable devices; telemedicine, Applications of Biomedical Engineering in Dentistry, Int. ; et al. ; Crespo, K.A.N.

Microfluidic devices are considered mobile devices because a sample analysis can be performed entirely within the small, portable device [, A POCT is a portable device used for analysis and detection outside a conventional laboratory [, Microfluidic systems have had a substantial influence on the applications of POCTs in medical diagnosis. ; Vessella, R.L. ; Yu, J.; Xie, J.; Xiang, J.J.; Wang, H. Two desired epitopes of cTnI benefit for preparation of standardized monoclonal antibodies. ; Tarantini, I.; Ferrara, F. Innovative 3D microfluidic tools for on-chip fluids and particles manipulation: From design to experimental validation. ; Wu, M.; Padhy, P.; Jensen, M.A. Chaparro, C.M. ; Hung, I.F.N. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. The future development of microfluidic chips is expected to continue to decrease their size and cost; therefore, more products for POC applications could soon be produced for the detection and treatment of cancer. ; Nilsson, M.; Madaboosi, N.; Russom, A. Sub-attomole detection of HIV-1 using padlock probes and rolling circle amplification combined with microfluidic affinity chromatography. Detection of multiple biomarkers for cardiovascular disease, C-reactive protein (CRP), troponin I (cTnI), and procalcitonin (PCT).

Martinez, A.W.

; Raji, H.; Mushnoori, S.; Javanmard, M. Potential microfluidic devices for COVID-19 antibody detection at point-of-care (POC): A review. Kaptoge, S.; Pennells, L.; De Bacquer, D.; Cooney, M.T. Therefore, the three indicators of glucose, triglycerides, and total cholesterol must be measured simultaneously to monitor diabetes and hyperlipidemia in real-time. First, utilizing PDMS to produce chips is not suitable due to a great demand for the output of chips in large-scale production. Dong, M.; Wu, J.; Ma, Z.; Peretz-Soroka, H.; Zhang, M.; Komenda, P.; Tangri, N.; Liu, Y.; Rigatto, C.; Lin, F. Rapid and low-cost CRP measurement by integrating a paper-based microfluidic immunoassay with smartphone (CRP-Chip). ; Adams, A.N. Many biomarkers have been identified for AMI diagnosis, including troponin I (cTnI), H-FABP, and copeptin. ; Yetisen, A.K. Detection and localization of surgically resectable cancers with a multi-analyte blood test. ELISA is primarily a plate-based assay. Boonkaew, S.; Jang, I.; Noviana, E.; Siangproh, W.; Chailapakul, O.; Henry, C.S. World health organization cardiovascular disease risk charts: Revised models to estimate risk in 21 global regions. This work presents a novel diagnostic strategy for advancing personalized medicine and mobile healthcare.

; Stracensky, T.; Gamez, K.; Dibiase, D.; Rusling, J.F. Multiplexed single molecule immunoassays. Modeling brownian microparticle trajectories in lab-on-a-chip devices with time varying dielectrophoretic or optical forces. ; Mackay, D.; Lewsey, J.; Gray, S.R. ; Bethel, C.; Hunt, C.; Gillen, S.; Moran, A.; Tesic, V. Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies.

Mass spectrometry in high-throughput proteomics: Ready for the big time.

; Marijon, E.; Anstey, N.M.; Woo, K.S.

Filella, X.; Albaladejo, M.D. Waheed, S.; Cabot, J.M. ; Bansal, H.; Sharma, D. Comparison of salivary and serum glucose levels in diabetic patients. Most protein biomarkers produced by the human body are released into the blood, urine, or other fluids and thus can be detected in these fluids [, Wearable devices may also become common in the POC detection of CVDs. Paper-based microfluidic device using LAMP. Recently developed microfluidic platforms can effectively separate and detect exosomes from liquid biopsy and can achieve a higher sensitivity compared with conventional methods, enabling the detection of exosomes in future POC applications [, The detection of multiple disease biomarkers with high sensitivity and rapidity is critical for tiny liquid samples. ; Rad, M.B. Choong, C.-L.; Milne, W.I. Farshidfar, N.; Hamedani, S. The potential role of smartphone-based microfluidic systems for rapid detection of COVID-19 using saliva specimen. The system was validated satisfactorily with commercially available existing systems using human serum samples. ; Ramsey, J.M. Xu, D.; Huang, X.; Guo, J.; Ma, X.

Mabey, D.; Peeling, R.W. Chang, K.W. Thermoplastic polymers (used for FDM) or photocurable resins (used for SLA). The detection box is manufactured by 3D printing technology and it does not need to be heated by an external power supply, but through chemical heating to meet the conditions required for the experiment. Therefore, the development of and recovery from diseases can be determined by detecting antibodies. The method features multiple detection regions and multiple working electrodes that can simultaneously detect the three CVD biomarkers in a single sample with high selectivity and sensitivity [. Cardiovascular disease in the developing world: Prevalences, patterns, and the potential of early disease detection. Lim, W.Y. ; Green, L.S.

3D printed microfluidic devices: Enablers and barriers.

; Anderson, N.L. ; Hesselink, L.; Davis, R.W. School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China, Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada, Clinical Research Center, The Affiliated Wuxi Peoples Hospital, Nanjing Medical University, 299 Qingyang Road, Wuxi 214023, China. ScienceDirect is a registered trademark of Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V. Microfluidic platforms for point of care (POC) medical diagnostics. ; Chan, J.M.C. In Proceedings of the 2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT), Bethesda, MD, USA, 68 November 2017; pp. Polymer microfluidic devices. Towards practical sample preparation in point-of-care testing: User-friendly microfluidic devices.

Reynolds, R.; Dennis, S.; Hasan, I.; Slewa, J.; Chen, W.; Tian, D.; Bobba, S.; Zwar, N. A systematic review of chronic disease management interventions in primary care. ; Clark, M.F. Expensive professional testing instruments must be placed in research laboratories, and their complex operation requires trained professionals. Symp. ; Chow, C.K.

; Song, L.; Piech, T.; Patel, P.P. Jalal, U.M. ; Sterling, D.G. ; Butte, M.J.; Whitesides, G.M. We use cookies to help provide and enhance our service and tailor content and ads.

Although 3D microfluidic chips are still less precise relative to traditional PDMS microfluidic chips, 3D printing technology is useful for producing microfluidic POCTs. The Feature Paper can be either an original research article, a substantial novel research study that often involves published in the various research areas of the journal. Paper chips are fast and inexpensive analysis platforms for the early diagnosis and treatment of diseases.

The detection was rapid and inexpensive and thus could be used to improve the prognosis of chronic heart and kidney disease [, Diabetes is another complex chronic disease; diabetes is a metabolic disorder that manifests as hyperglycemia caused by insufficient insulin secretion. Byagathvalli, G.; Pomerantz, A.F. Analysis of hemoglobin glycation using microfluidic CE-MS: A rapid, mass spectrometry compatible method for assessing diabetes management. ; Flores, M.T.A. ; McChesney, D.; Seville, J.; et al. These wearable devices can also continuously transmit biological data to the internet in real time, so as to convert this information into clinical knowledge for monitoring the physical condition of patients [, Traditional immune monitoring requires trained personnel and specialized equipment. Voller, A.; Bartlett, A.; Bidwell, D.E. Microfluidic system integrated with a diagnostic microchip and portable fluorescence detector. ; Albert, M.A. Platforms integrating smartphones with microfluidic equipment are often effective for microfluidic POC applications and handheld microfluidic centrifugal devices and microfluidic POC devices using DEP technology are another avenue for microfluidic POC detection. ; Wang, Q.

Kim, P.; Kwon, K.W. Additionally, those in the microfluidic field should increase their investment in biomedical applications and attempt to increase the adoption of microfluidics in clinical trials. Ameh, S.; Klipstein-Grobusch, K.; DAmbruoso, L.; Kahn, K.; Tollman, S.M. ; Hraha, T.; Russell, T.M. The microfluidic chips used in laboratory medicine are representative of this technology. The first paper-based microfluidic device was designed by Whitesides et al., in 2007 [, Because paper is cheap, it is particularly popular for applications requiring a low cost, easy operation, and rapid analysis, such as for disease diagnosis in low and medium resource areas [, Paper-based microfluidic chips can be applied to analyze various analytes in the human body, including urine, saliva, blood, tears, and other bodily or exocrine fluids.

There are many on-site detection and diagnosis POC devices in the market, including but not limited to glucose detection and infectious disease monitoring; however, among the POC detection devices, microfluidic POC devices with POC integrated microfluidic technology occupy the vast majority of the share, because microfluidic POC devices can allow fluid operation and detection to be carried out in the same device, which is more integrated than non-microfluidic POC devices. ; Zhang, H.R. The commercialization of microfluidics is subject to customer and market acceptance. Mohammed, M.I. Microfluidic POC devices have better integration. ; Butt, H.; Khademhosseini, A.; et al. ; Sannam Khan, R. Role of salivary biomarkers in detection of cardiovascular diseases (CVD). ; Chan, K.S.

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy. Ray, A.; Esparza, S.; Wu, D.; Hanudel, M.R. Ramasamy et al., designed a sensor system that can be worn on the body. DNA methylation of tumor suppressor genes.

; Cassell, G.H. Han et al., designed a laterally driven continuous dielectric electrophoresis (DEP) differentiator, which can effectively separate red blood cells and white blood cells in whole blood samples [. Meja-Salazar, J.R.; Cruz, K.R. Squires, T.M. System integrating dielectrophoresis (DEP), graphene field-effect transistors (FETs) and a compact discbased microfluidic. ; Jiang, N.; Tamayol, A.; Ruiz-Esparza, G.U. Engvall, E.; Perlmann, P. Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Liu, H.; Lei, Y. Li et al., improved the system and designed a paper-based integrated diagnosis system.